Improving Metabolism With HDL Cholesterol

A Novel Mechanism Mediating Anti-atherosclerotic and Metabolic Actions of HDL Cholesterol

High levels of good cholesterol (HDL) in our blood decreases our chance of having a heart attack. This relates in part to the role good cholesterol plays in reducing build up of fat in the arteries. However, good cholesterol has many other protective effects. We have recently identified three enzymes (proteins) activated by HDL in cells lining the blood vessels, which may be responsible for some of HDL's protective actions.

Inclusion Criteria:

• Aged 18 - 65 years
• Free of overt coronary disease
• Body mass index <35 kg.m-2
• Fasting plasma glucose > 7 mmol/L-1
• No major illness

Exclusion Criteria:

• Unable to give informed consent
• Smokers
• Abnormal LFT, U&E, FBE or creatinine