Primary Objective: In subjects who have undergone segmental colectomy, the time between the end of surgery and first bowel movement is significantly shorter with the investigational MOA-728 regimen than with a placebo regimen.

Inclusion:

• Must be scheduled for a segmental colectomy via open laparotomy with general anesthesia
• Subjects with history of inflammatory bowel disease are eligible as long as the disease is not currently active and all other criteria are met
• Subjects must meet the American Society of Anesthesiologists physical status I, II or III

Exclusion:

• Subjects who are scheduled for laparoscopic surgery for the segmental colectomy
• Subjects with a recent history (<1 year prior to randomization) of abdominal radiation therapy; Subjects with a history of small bowel obstruction, known or suspected bowel adhesions (other than minor, clinically nonsignificant adhesions)
• Subjects undergoing operations resulting in gastrointestinal ostomies, or who require use of post operative nonsteroidal anti-inflammatory drugs (NSAIDs)