A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of Intravenous Methylnaltrexone (MOA-728) for the Treatment of Post Operative Ileus After Ventral Hernia Repair
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study of Intravenous Methylnaltrexone (MOA-728) for the Treatment of Post Operative Ileus After Ventral Hernia Repair
This study will evaluate the safety and efficacy of two different dose regimens (12 milligrams [mg] and 24 mg) of IV MOA-728 versus placebo in shortening the time to return of bowel function in participants receiving opioid analgesia administered via patient-controlled anesthesia (PCA), and who had undergone repair of large (greater than or equal to [≥]10 centimeters) ventral hernias with or without a mesh prosthesis via laparotomy or laparoscopy.
Inclusion Criteria:
Exclusion Criteria:
Adelaide SA, 5006, Australia
Elizabeth Vale SA, 5112, Australia
Wilrijkstraat 10, Edegem 2650, Belgium
De Pintelaan 185, Gent Belgium 9000, Belgium
Nussbaumstrasse 20, Muenchen 80336 DEU, Germany
Augustenburger Platz 1, State of Berlin 13353 DEU, Germany
Corso Giovecca 203, Ferrara 44100, Italy
Gemelli, Rome 00168, Italy
Jan Toorpstraat 164, Amsterdam 1061, Netherlands
Powstancow Wielkopolskich 72, Szczecin 70-111, Poland
Polnocna 42, Łódź Voivodeship 91 425, Poland
Durban Kwa-Zulu, KwaZulu-Natal 3201, South Africa
Moreletapark Pretoria, 0044, South Africa
Pretoria Gauteng, 0084, South Africa
Pretoria Gauteng, 0181, South Africa