Not provided
Not provided
Not provided
Not provided
Not provided
Premature termination following the departure of the principal investigator. No replacement investigator. Management decision.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Epileptic disease is characterised by enhanced brain excitability. Low frequency repetitive transcranial magnetic stimulation (rTMS) can be an effective treatment for refractory frontal epilepsy. Thought, physiological mechanisms of its effectivity are still unknown. It is yet possible to evaluate cortical excitability and inhibition with TMS-coupled electromyography before and after rTMS sessions ; this could provide clues for basic mechanisms of rTMS effects on the epileptic brain. We assume that rTMS decrease brain excitability by improving brain inhibition. Such an information could help for treating patients with both pharmacological and non-pharmacological methods.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cortical magnetic stimulation provided by an eight-shaped coïl placed upon the skull. | Device |
| Measure | Description | Time Frame |
|---|---|---|
| Electrophysiological parameters for cortical excitability measured just before and after rTMS, 4 hours later and 24 hours later. |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical efficacity on seizure intensity and frequency. |
Not provided
Inclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Serge CHASSAGNON, MD | Hôpitaux Universitaires de Strasbourg | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Département de Neurologie - Hôpital Civil | Strasbourg | 67091 | France | |||
| Institut de Physique Biologique |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Strasbourg |
| 67091 |
| France |
| ID | Term |
|---|---|
| D017034 | Epilepsy, Frontal Lobe |
| ID | Term |
|---|---|
| D004828 | Epilepsies, Partial |
| D004827 | Epilepsy |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D000073376 | Epileptic Syndromes |
Not provided
Not provided