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This study will investigate the application of a vasopressin antagonist in the treatment of hyponatremia most likely caused by inappropriate AVP secretion. The population studied will include patients with euvolemic or hypervolemic hyponatremia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Lower dose |
|
| 2 | Experimental | Higher dose |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| conivaptan | Drug | IV |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Baseline-adjusted change in AUC for serum sodium | 96 Hours |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of safety between patients in each study arm | 96 Hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Art Wheeler, MD | Cumberland Pharmaceuticals, Inc. | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tuscon | Arizona | 85723 | United States | |||
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| Denver |
| Colorado |
| 80262 |
| United States |
| Washington D.C. | District of Columbia | 20007 | United States |
| Augusta | Georgia | 30901 | United States |
| Petoskey | Michigan | 49700 | United States |
| Cincinnati | Ohio | 45219 | United States |
| Columbia | South Carolina | 29209 | United States |
| Afula | Israel |
| Ashkelon | Israel |
| Hadera | Israel |
| 2 Sites | Haifa | Israel |
| Holon | Israel |
| 2 Sites | Jerusalem | Israel |
| Nahariya | Israel |
| Rehovot | Israel |
| 2 Sites | Safed | Israel |
| Tel Aviv | Israel |
| Ẕerifin | Israel |
| Amanzimototi | South Africa |
| Bellville | South Africa |
| Bloemfontein | South Africa |
| 2 Sites | Durban | South Africa |
| 4 Sites | Johannesburg | South Africa |
| Krugersdorp | South Africa |
| Lyttelton | South Africa |
| Pretoria | South Africa |
| Somerset West | South Africa |
| Soweto | South Africa |
| ID | Term |
|---|---|
| D007010 | Hyponatremia |
| ID | Term |
|---|---|
| D014883 | Water-Electrolyte Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| C106389 | conivaptan |
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