A Study of Multiple Dosing Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia

A Phase 4, Randomized, Parallel Group, Multi-Center Study to Assess the Safety and Efficacy of Multiple Dosing Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia

The study will evaluate the effectiveness and safety of multiple dosing regimens of IV conivaptan in subjects with euvolemic or hypervolemic hyponatremia

Inclusion Criteria:

• Subject has a serum sodium value between 115 and 133 mEq/L
• Subject is euvolemic or hypervolemic

Exclusion Criteria:

• Clinical evidence of volume depletion or dehydration
• Uncontrolled brady- or tachyarrhythmias requiring emergent pacemaker placement or treatment