Safety Study of Stopping Thromboprophylaxis Based on Ultrasound Results After Total Knee Replacement

9-10 Days Versus Prolonged Thromboprophylaxis in Patients Without Evidence of Ultrasound Proximal Thromboembolism After Total Knee Joint Replacement: a Randomized Controlled Trial

The purpose of this study is to determine whether stopping Low Molecular Weight Heparin (LMWH) thromboprophylaxis is safe after total knee joint replacement. The investigators select patients without proximal thromboembolism assessed by bilateral venous ultrasound examination 7-10 days after surgery. the investigators hypothesis is that stopping thromboprophylaxis is equally effective than prolonging thromboprophylaxis in order to prevent post-surgery complications in this population.

Inclusion Criteria:

• First total knee joint replacement
• Signed informed consent

Non-inclusion Criteria:

• History of venous thromboembolism/major bleeding/Heparin induced thrombopenia
• Active cancer
• Long-term anticoagulation