Phase IIa Venous Thromboembolism (VTE) Prevention Study In Total Knee Replacement (TKR)

Dose Ranging Trial for the Evaluation of the Safety and Efficacy of GW813893 in the Prophylaxis of Venous Thromboembolism Post Total Knee Replacement Surgery.

This study was designed to assess the safety and efficacy of GW813893 in the prophylaxis of VTE following TKR and to provide evidence to enable the selection of the appropriate dose(s) and dose regimen of GW813893 for future investigation.

Inclusion criteria:

• Patients who are scheduled for primary elective unilateral total knee arthroplasty.

Exclusion criteria:

• Women who are not surgically sterile or post-menopausal
• Have a contra-indication to contract venography
• Have a known disorder associated with increased risk of bleeding or have been immobile up to 12 weeks before surgery.