Comparison Study of Transarterial Chemoembolization and Percutaneous Ethanol Injection for Multiple, Small HCCs

A Multicenter, Randomized, Controlled Trial of the Effective Therapy for Multiple, Small Hepatocellular Carcinomas: Comparing Transarterial Chemoembolization With Percutaneous Ethanol Injection Therapy.

The purpose of this study is to choose the preferred treatment modality for multiple, small hepatocellular carcinomas.

To compare the below things between PEIT group and TACE group

1. Survival

   1. 5 year overall survival rate
   2. Disease free survival rate

2. Recurrence a. recurrence rate

Inclusion Criteria:

• The evidences of HBV(+) &/or HCV(+) infection or liver cirrhosis
• Two to three tumor nodules with Child-Pugh classification A or single to three tumor nodules with Child-Pugh classification B
• The maximal, longest diameter of tumor mass measured by CT finding should be less than 2 cm.
• 1) Only for newly detected HCCs which were not treated before or 2) If treated before, it should be noted that there is no evidence of recurrence within the latest 6 months and, and also it should be remotely recurred more than 2cm apart from primary lesion.
• It should be compatible with the typical findings of HCCs radiologically(MD CT or dynamic MRI)

Exclusion Criteria:

• In case of hepatic vein or portal vein invasion radiologically(CT or MRI)