Comparison Study of Operation and PEIT for Small, Solitary Hepatocellular Carcinoma (HCC)

Prospective Randomized Trial of the Effective Therapy for Small, Solitary HCC Comparing Operation and Percutaneous Ethanol Injection Therapy

The purpose of this study is to choose the preferred treatment modality for solitary, small hepatocellular carcinoma.

To compare the below things between operation group and percutaneous ethanol injection therapy (PEIT) group:

1. Survival

   • 5 year overall survival rate
   • Disease free survival rate

2. Recurrence

   • Cumulative recurrence rate

Inclusion Criteria:

• The evidences of hepatitis B virus (HBV)&/or hepatitis C virus (HCV) infection or liver cirrhosis
• Single tumor nodule with Child-Pugh classification A (serum albumin ≥ 3.2 g/dL)
• The maximal, longest diameter of tumor mass measured by CT finding should be less than 2 cm
• Only for the newly detected HCCs which were not treated before
• It should be compatible with the typical finding of hepatocellular carcinomas (HCCs) radiologically (MD CT or dynamic MRI)
• Without portal hypertension

Exclusion Criteria:

• In case of hepatic vein or portal vein invasion radiologically (CT or MRI)