CBT With Disulfiram and Contingency Management

Maximizing the Efficacy of Cognitive Behavioral Therapy With Medication and Contingency Management

This is a study of four treatments for chronic cocaine use and may help study participants to control their drug use. All participants will receive weekly individual cognitive behavioral therapy (CBT).

This study will compare four types of treatment involving skills training and incentives for attending sessions or taking study medication. Disulfiram is a widely prescribed deterrent to alcohol use. In addition to weekly cognitive behavioral therapy (CBT), participants will be assigned to one of the following treatments:

1. placebo
2. disulfiram
3. placebo plus incentives for cocaine abstinence and medication compliance (prize CM)
4. disulfiram plus incentives for cocaine abstinence and medication compliance

Inclusion Criteria:

• 18-50 year old
• cocaine dependent
• willing to sign consent
• willing to accept randomization to intervention

Exclusion Criteria:

• significant medical conditions
• psychiatric disorder with current use of prescribed psychotropic medication
• lifetime schizophrenia or bipolar disorder
• suicidality or homicidality
• unlikely to be able to complete 1 year follow up
• unable to speak or read English at a third grade level