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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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Cognitive-behavioral coping skills therapy (CBT) is a widely used and recognized treatment that has been empirically validated for a range of substance use disorders, often with emergent effects and continuing improvement even after treatment ends. Treatment retention and compliance are associated with enhanced treatment outcomes in CBT. Contingency management (CM) also has very strong support and is associated with rapid, robust effects on targeted outcomes. Despite their many strengths, neither CBT nor CM is universally effective. It is now essential to seek strategies to maximize and extend the effectiveness of these two approaches and to better understand how these treatments exert their effects.
The investigators propose to evaluate targeted strategies to maximize the effectiveness of CBT and CM, respectively. To maximize the effectiveness of CBT, the investigators will evaluate the benefit of adding CM, with reinforcement for session attendance and homework completion, to standard individual CBT for outpatient marijuana abusers, in order to expose participants to more skill training and opportunities for practice of skills. To maximize the effectiveness and durability of CM, we will evaluate the benefit of integrating it with skills training, specifically designed to reduce drop off effects, in order to extend CM's benefits beyond the active treatment period. We propose to conduct a Stage II trial which will: (1) Evaluate the efficacy of four conditions for 160 marijuana dependent outpatients: (a) Standard CBT, (b) CBT with CM reinforcement for attendance and completing homework (CBT+CM/adherence), (c) CM for abstinence alone (CM/abstinence), (d) CM for abstinence integrated with CBT (CM/abstinence+CBT), and (2) Evaluate the longer-term durability and / or delayed emergence of treatment effects after termination of the study treatments through a one-year follow-up. Secondary aims will be to conduct (a) detailed process studies to evaluate whether the proposed enhancements affect proximal and distal outcomes as hypothesized and (b) economic analyses. Study treatments will last 12 weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | manualized delivery of CBT by trained clinicians |
|
| 2 | Active Comparator | CBT with Contingency Management reinforcement for attendance and completing homework (CBT+CM/adherence) |
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| 3 | Experimental | Contingency Management for abstinence alone (CM/abstinence) |
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| 4 | Active Comparator | Contingency Management integrated with CBT (CM/abstinence+CBT) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard CBT | Behavioral | Manualized delivery of CBT by trained clinicians |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Self reported marijuana use (days of abstinence by week) and results of urine toxicology screens | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Economic analysis with use of PACC-SAT | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kathleen Carroll, PhD | Yale University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ASAP/1 Long Wharf | New Haven | Connecticut | 06512 | United States |
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| ID | Term |
|---|---|
| D002189 | Marijuana Abuse |
| D064829 | Alcohol Abstinence |
| D010349 | Patient Compliance |
| D001519 | Behavior |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
| D004327 | Drinking Behavior |
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| CBT+CM/adherence |
| Behavioral |
CBT and Clinical Management for attendance and completing homework |
|
| CM/abstinence | Behavioral | Contingency Management |
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| CM/abstinence+CBT | Behavioral | Contingency Management for abstinence in addition to manualized CBT delivered by a trained clinician |
|
| D010342 | Patient Acceptance of Health Care |
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |