Study to Evaluate Plasmin for the Creation of a Posterior Vitreous Detachment

A Multicenter, Randomized, Double Masked, Placebo Controlled, Sequential Dose Response Study of Intravitreally Administered Plasmin for the Creation of a Posterior Vitreous Detachment (PVD)

Plasmin is expected to create a posterior vitreous detachment. The pharmacological creation of a posterior vitreous detachment may be beneficial in a variety of conditions.

Inclusion Criteria:

• Patients who would benefit from a posterior vitreous detachment, as determined by the evaluating ophthalmologist.

Exclusion Criteria:

• Presence of a posterior vitreous detachment in the study eye
• History of vitrectomy in the study eye
• Proliferative diabetic retinopathy in the study eye
• Presence of media opacity that precludes quality examination of the vitreous and fundus.