A Study to Evaluate Plasmin for the Creation of a Posterior Vitreous Detachment (PVD)

An Open Label Sequential Dose Response Observational Study of Intravitreally Administered Plasmin for the Creation of a Posterior Vitreous Detachment (PVD)

Plasmin is expected to create a posterior vitreous detachment (PVD) when injected directly into the eye. The pharmacological creation of a PVD may be beneficial in helping to treat a variety of conditions.

Inclusion Criteria:

• Patients who are in need of a vitrectomy.

Exclusion Criteria:

• A PVD in the study eye as assessed by the investigator using ophthalmic and alternative examination techniques.
• A history of vitrectomy in the study eye.
• A media opacity that precludes quality examination of the vitreous and fundus in the study eye.