Irbesartan in Chinese Hypertensive Diabetics With Microalbuminuria

A Study of Irbesartan 150mg Verses 300mg in Chinese Hypertensive Patients With Diabetes and Microalbuminuria

Primary objective:

• To determine if irbesartan 300mg is better than 150mg in protecting the kidneys in hypertensive patients with diabetes and microalbuminuria.

Secondary objectives:

• To determine how well irbesartan 300mg is tolerated versus 150mg
• To determine the percentage of patients reaching the blood pressure target of 130/80 mmHg

Inclusion Criteria:

• Hypertensive patients, treated or untreated, with type 2 diabetes and urinary albumin excretion rate 20-200ug/min.
• Blood pressure of < 180/110mmHg at baseline
• Normal serum creatinine

Exclusion Criteria:

• Type 1 diabetes
• Use of angiotensin converting enzyme inhibitors or angiotensin receptor blockers in the 5 weeks before recruitment
• Pregnant or lactating women
• Severe hypertension
• Overt nephropathy
• Allergy to study drug

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.