Effects Of Prednisolone On Rheumatoid Arthritis Patients

A Study of the Pharmacodynamic Effects of Prednisolone on Whole Blood Protein and Gene Expression in Rheumatoid Arthritis Patients

This study will assess the Pharmacokinetic (PK) and Pharmacodynamic (PD) effects of Prednisolone on Rheumatoid Arthritis (RA) patients.

Inclusion criteria:

• Meet the ACR criteria for diagnosis of rheumatoid arthritis.
• Required treatment with Prednisolone.
• Currently on a non-steroidal anti-inflammatory agent (NSAID).
• Willing to stay on current dose of NSAID for two weeks during study.

Exclusion criteria:

• Major health issues such as osteoporosis, diabetes, heart failure, heart attack, kidney failure, or acute infection.