This study will assess the Pharmacokinetic (PK) and Pharmacodynamic (PD) effects of Prednisolone on Rheumatoid Arthritis (RA) patients.

Inclusion criteria:

• Meet the ACR criteria for diagnosis of rheumatoid arthritis.
• Required treatment with Prednisolone.
• Currently on a non-steroidal anti-inflammatory agent (NSAID).
• Willing to stay on current dose of NSAID for two weeks during study.

Exclusion criteria:

• Major health issues such as osteoporosis, diabetes, heart failure, heart attack, kidney failure, or acute infection.

A Study of the Pharmacodynamic Effects of Prednisolone on Whole Blood Protein and Gene Expression in Rheumatoid Arthritis Patients and pharmacodynamic effects on whole blood gene and protein expression.