Efficacy of Metformin in Lean Women With Polycystic Ovary Syndrome

Insulin resistance is an important feature of the polycystic ovary syndrome,and patiens are successfully treated with the insulin sensitizing agent metformin. The insulin resistance of lean patients with the syndrome is debated. In this study, we will study the change in insulin resistance, metabolic and hormonal factors after 3 months of metformin treatment in lean PCOS women.

Inclusion Criteria:

• PCOS (Rotterdam criteria)
• BMI < 27
• No medication for 3 months

Exclusion Criteria:

• Pregnancy
• Lactation
• Other endocrinologic disease