Efficacy of Metformin in PCOS: Metabolic and Hormonal Factors

Hypothesis: Metformin treatment normalises hormone values and metabolic parameters in women with PCOS. Ovulation is restored and bleeding periods become regular.

Fifty women with PCOS (Rotterdam criteria) are randomised to either placebo or metformin for 6 months. After a wash-out period of 3 months, the opposite treatment is given for another 6 months. Measurements are performed before ech treatment period, every second month during treatment and after completing treatment.

Inclusion Criteria:

• Diagnosis of PCOS
• Age 20 - 45

Exclusion Criteria:Diabetes

• Diabetes
• Hormonal treatment
• Pregnancy, lactation
• Periclimacteric