AutoCPAP would lead to better compliance than FixCPAP

A prospective, randomized crossover cohort. Study subjects consisted of patients newly diagnosed with obstructive sleep apnea (OSA) confirmed with sleep study. All are CPAP naïve.

Randomization:

Arm 1: auto CPAP sleep study then auto CPAP for 2 months Arm 2: fixed CPAP titration then fixed CPAP for 2 months

Then switch over to the other arm

Trial end after 4 months, compliance and other parameters would be compared between two arms as described in the endpoint session.

Inclusion Criteria:

• All subjects should be CPAP naïve.
• OSA confirmed with sleep study
• Presence of daytime symptoms with excessive daytime sleepiness
• Age between 18 to 65
• RDI greater than 30
• Agreed to participate in trial with informed consent signed

Exclusion Criteria:

• Patients not suitable to nasal CPAP because of facial abnormality leading to poor mask fitting.
• Patients with known COPD with type II failure
• Patients with known heart failure.
• Patients with predominant central sleep apnea.
• Patients need bilevel positive airway pressure ventilation.
• Patients refusing to participate the trial.
• Patients have difficulty to follow up regularly.
• patients with untreated or under treatment of hypothyroidism