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| ID | Type | Description | Link |
|---|---|---|---|
| NYU-H-8896-06-B |
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RATIONALE: Screening tests that use biomarkers may help doctors find tumor cells early and plan effective treatment for lung cancer.
PURPOSE: This clinical trial is studying biomarkers in screening participants for lung cancer.
OBJECTIVES:
OUTLINE: Participants are stratified according to lung cancer risk status (with or without increased risk).
Group 1 (screening cohort): Participants complete a questionnaire and undergo pulmonary function testing, multidetector chest CT scan, sputum induction, and phlebotomy.
Group 2 (rule-out lung cancer): Participants complete the same questionnaire and undergo the same tests and scans as in group 1. Some participants may undergo fiberoptic bronchoscopy based upon CT scan results with transbronchial or endobronchial biopsies. Some participants may undergo lung resection. Tissue samples are collected from surgery or biopsy.
PROJECTED ACCRUAL: A total of participants will be accrued for this study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| lung cancer screening cohort | observational only. no intervention. current, former and never smokers over age 50 without history of cancer, except for non melanoma skin cancer, no previous treatment with chemotherapy. | ||
| r/o lung cancer | observational only. no intervention. patients with CT findings suspicious for lung cancer who are undergoing bronchoscopy and/or surgery. |
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| Measure | Description | Time Frame |
|---|---|---|
| Lung cancer diagnosis as measured by CT scan findings and pathology findings annually | 07/01/2015 |
| Measure | Description | Time Frame |
|---|---|---|
| Precancerous lung nodules as measured by CT scan findings and pathology findings annually | 07/01/2015 |
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DISEASE CHARACTERISTICS:
Screening Cohort
At high- or low-risk for lung cancer
Smoking history ≥ 20 pack years*
NOTE: * Participants with < 20 pack years of smoking are eligible if 50 years of age or older
Rule-Out Lung cancer group
Referred for evaluation of suspicious nodules with 1 of the following diagnoses:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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healthy subjects at risk for lung cancer and controls from community, private physician referrals, local trade unions, employee health fairs, word of mouth and print advertisements.
patient referrals from physician outpatient offices and inpatients with CT findings suspicious for lung cancer.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| James J. Tsay, MD, MSc | Contact | 212-598-6351 | Jun-Chieh.Tsay@nyulangone.org | |
| Rosemary M Schluger | Contact | 212-263-0255 | rosemary.schluger@nyulangone.org |
| Name | Affiliation | Role |
|---|---|---|
| James J. Tsay, MD, MSc | NYU Langone Health | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| NYU Cancer Institute at New York University Medical Center | Recruiting | New York | New York | 10016 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17934114 | Result | Greenberg AK, Rimal B, Felner K, Zafar S, Hung J, Eylers E, Phalan B, Zhang M, Goldberg JD, Crawford B, Rom WN, Naidich D, Merali S. S-adenosylmethionine as a biomarker for the early detection of lung cancer. Chest. 2007 Oct;132(4):1247-52. doi: 10.1378/chest.07-0622. | |
| 22768300 | Result | Greenberg AK, Lu F, Goldberg JD, Eylers E, Tsay JC, Yie TA, Naidich D, McGuinness G, Pass H, Tchou-Wong KM, Addrizzo-Harris D, Chachoua A, Crawford B, Rom WN. CT scan screening for lung cancer: risk factors for nodules and malignancy in a high-risk urban cohort. PLoS One. 2012;7(7):e39403. doi: 10.1371/journal.pone.0039403. Epub 2012 Jul 2. |
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| ID | Term |
|---|---|
| D008175 | Lung Neoplasms |
| D055752 | Small Cell Lung Carcinoma |
| D002289 | Carcinoma, Non-Small-Cell Lung |
| ID | Term |
|---|---|
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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blood serum, plasma, urine, sputum, BAL, lung tissue, buccal swab
| 20504322 | Result | Rom WN, Goldberg JD, Addrizzo-Harris D, Watson HN, Khilkin M, Greenberg AK, Naidich DP, Crawford B, Eylers E, Liu D, Tan EM. Identification of an autoantibody panel to separate lung cancer from smokers and nonsmokers. BMC Cancer. 2010 May 26;10:234. doi: 10.1186/1471-2407-10-234. |
| D008171 |
| Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |