Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression

Phase 4 Study on the Effect of Partial Sleep Deprivation on Cognition and the IL-6-gp130-System in Individuals With Major Depression

40 patients with the diagnosis of major depression are included. There are two interventions: partial sleep deprivation (PSD) and normal night sleep (CTRL). Patients are randomly assigned to PSD-(2 undisturbed nights)-CTRL or CTRL-(2 undisturbed nights)-PSD. Cytokine-status, neuropsychological and psychopathometric status are assessed pre and post each interventional and control condition.

Inclusion Criteria:

• Major depression
• Informed consent

Exclusion Criteria:

• Known epilepsy or previous unexplained loss of consciousness after sleep deprivation
• Bipolar disorder
• Acute or chronic inflammatory diseases
• Psychosis
• Suicidal tendency
• Pregnancy or nursing