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Already get the approval by Ethics Committee of Peking Union medical college and Johns Hopkins Hospital.
Although it was often to hear that malnutrition ratio in Aisa hospitalized patient was 40%-70% , there was no evidence to elaborate the prevalence of nutritional risk and malnutrition on hospitalized patients of Asia. Also in USA no data for nutritional risk. In 2002, scientists group headed by Kondrup from : European Society for Parenteral and Enteral Nutrition demonstrated that randomized controlled clinical trials showed patients may get benefit from nutrition support when they with nutrition risk. Based on these evidences, a simpler method was established by European Society for Parenteral and Enteral Nutrition in year 2002 in Munich & it was demonstrated useful to evaluate the appropriate use of nutrition support at present time. This method was named as Nutrition Risk Screening (NRS).
We propose to survey the prevalence of malnutrition & nutrition risk in large cities' large/middle size hospitalized patients in China, Europe and USA use NRS tool. As well, we also aim to figure out the current nutrition support status in current large/middle size hospitals through this survey.
we also propose to evaluate the cost-effectiveness of parenteral nutrition, enteral nutrition and non-nutritional support, and to examine the clinical outcomes of nutritional support in certain patients at nutritional risk identified by NRS-2002.
For international cooperation,our partners are Professor Kondrup of Europe and Professor Nolan from Johns Hopkins Hospital,there are students from a cooperative project with Johns Hopkins Hospital for Doctor of Philosophy students 2005-2011.
In plan this protocol might be completed around 2016 also.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nutrition support | Nutrition support cohort means accept nutrition support，it was defined as ≥15kal/kg/d and < 30kal/kg/d of non-protein calories (carbohydrate and/or fat) and amino acids or protein≥1g/kg/d for 5~28 consecutive days. | ||
| Without nutritional support | Group received only intravenous 5 to 10% glucose and electrolyte infusions |
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| Measure | Description | Time Frame |
|---|---|---|
| Infectious complication | A infectious complication was defined as as the presence of recognized pathogens in body tissues that normally are sterile, confirmed by the results of culture and supported by clinical, radiologic or hematologic evidence of infection | Observation will be carried from admitting end until discharge |
| Measure | Description | Time Frame |
|---|---|---|
| cost effectiveness | The cost effectiveness analysis was performed from the payers' perspective.The percentage of infectious complication-free patients was used to measure the effectiveness. The total cost was considered to contain 3 items in our study. The first item was the cost of nutrition support, including nutrition solutions, nursing, physician, and other staff supervision of nutrition support preparation, administration, and catheter placement and maintenance. The second item was the cost of the infectious complication.The third item was 'other costs' associated with the hospital admission, calculated from the total costs from which the cost of nutrition support and infectious complications were subtracted. The incremental cost-effectiveness ratio (ICER) was calculated by dividing the costs difference between the nutrition support cohort and no-nutrition support cohort by their difference in effectiveness. |
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Inclusion Criteria:
Exclusion Criteria:
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Continuing sampling in 6 clinical Departments of large, middle & small size hospitals in 15 large cities from West, Middle & East China.
Also, data from Denmark and USA will be collected and analysed.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zhu-Ming Jiang, M.D., FACS | Contact | +86 186 0114 8800 | jiangzm@imicams.ac.cn, jiangzhm@pumch.cn | |
| Kang Yu, M.S. | Contact | +86 13801130457 | yuk2004@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Zhu-ming Jiang, M.D., FACS | Peking Union Medical College Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Friendship Hospital, Capital Medical University | Active, not recruiting | Beijing | Beijing Municipality | 100730 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19963351 | Derived | Jie B, Jiang ZM, Nolan MT, Efron DT, Zhu SN, Yu K, Kondrup J. Impact of nutritional support on clinical outcome in patients at nutritional risk: a multicenter, prospective cohort study in Baltimore and Beijing teaching hospitals. Nutrition. 2010 Nov-Dec;26(11-12):1088-93. doi: 10.1016/j.nut.2009.08.027. Epub 2009 Dec 5. |
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| ID | Term |
|---|---|
| D044342 | Malnutrition |
| D050177 | Overweight |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D044343 | Overnutrition |
| D001835 | Body Weight |
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| Observation will be carried from admitting end until discharge |
| Peking Union Medical College Hospital | Active, not recruiting | Beijing | Beijing Municipality | 100730 | China |
| Beijing Chest Hospital, Capital Medical University | Not yet recruiting | Beijing | Beijing Municipality | 101149 | China |
|
| Chongqing Medical Univ. Hospital | Completed | Chongqing | Chongqing Municipality | China |
| Xin Qiao Hospital | Recruiting | Chongqing | Chongqing Municipality | China |
|
| The First Affiliated Hospital, Sun Yat-sen University | Recruiting | Guangzhou | Guangdong | 510080 | China |
|
| The First Affiliated Hospial, Guangxi Medical University | Recruiting | Nanning | Guangxi | 530021 | China |
|
| The First University Hospital, Hebei Medical University | Recruiting | Shijiazhuang | Hebei | 050031 | China |
|
| Nankai Hospital | Active, not recruiting | Tianjin | Hebei | 300100 | China |
| Tongji Hospital, Huazhong University of Science and Technology | Recruiting | Wuhan | Hubei | 430030 | China |
|
| Nanjing General Hospital of Nanjing Military Command | Recruiting | Nanjing | Jiangsu | 210002 | China |
|
| Xin Hua Hospital, Shanghai Jiaotong University | Recruiting | Shanghai | Shanghai Municipality | 200029 | China |
|
| Sixth Hospital | Recruiting | Shanghai | Shanghai Municipality | China |
|
| The First Affiliated Hospital, Xinjiang Medical University | Active, not recruiting | Ürümqi | Xinjiang | 830054 | China |
| Second Affiliated Hospital, Zhejiang University | Active, not recruiting | Hangzhou | Zhejiang | 310006 | China |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |