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Neurology disorders are one of the major public health problems that seriously threaten human health. It often accompanied by various nutritional problems, which can aggravate the primary disease, lead to serious complications, prolong the hospitalization, lead to poor prognosis, and increase family and social economic burdens. According to the previous studies, the risk of malnutrition was approximately 58.5% of stroke patients, and 6% had moderate to severe malnutrition in China. Another study conducted in Beijing showed that the risk of malnutrition of elderly patients in the department of neurology was significantly higher than in other departments (28.5% vs. 26.4%). Strengthening nutritional supervision of patients with neurology disorders will benefit to improve patients' prognosis. Therefore, the aim of this study is to investigate the nutritional status of inpatients with neurology disorders in China, evaluate the impact of different nutritional status on patients' health outcomes, and establish a high-quality, standardized nutrition and health cohort database for neurology disorders.
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| Measure | Description | Time Frame |
|---|---|---|
| All-cause mortality | Mortality defined as all-cause mortality from inclusion to day 30 | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| ICU admission | ICU admission defined as admission to the intensive care unit from the medical ward from inclusion to day 30 | 30 days |
| Non-elective hospital readmission | Non-elective hospital readmission defined as non-scheduled hospital readmission after discharge from the index hospital stay to day 30 |
| Measure | Description | Time Frame |
|---|---|---|
| Adverse events | Each of the adverse events | 30 days |
Inclusion Criteria:
Exclusion Criteria:
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Participants with the primary diagnosis are neurological disoders
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gaoting Ma, PhD | Contact | 18301579891 | demo_doctor@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Junwei Hao, PhD | Capital Medical University Xuanwu Hospital | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34487721 | Background | GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2021 Oct;20(10):795-820. doi: 10.1016/S1474-4422(21)00252-0. Epub 2021 Sep 3. | |
| 32826385 | Background | Wang YJ, Li ZX, Gu HQ, Zhai Y, Jiang Y, Zhao XQ, Wang YL, Yang X, Wang CJ, Meng X, Li H, Liu LP, Jing J, Wu J, Xu AD, Dong Q, Wang D, Zhao JZ; China Stroke Statistics 2019 Writing Committee. China Stroke Statistics 2019: A Report From the National Center for Healthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations. Stroke Vasc Neurol. 2020 Sep;5(3):211-239. doi: 10.1136/svn-2020-000457. Epub 2020 Aug 21. |
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| ID | Term |
|---|---|
| D009422 | Nervous System Diseases |
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| 30 days |
| Major complications | Major complications defined as the following complications occurring from inclusion (i.e., not present at the time of inclusion) to day 30 I. Adjudicated nosocomial infection or abscess requiring antibiotic treatment II. respiratory failure with need for invasive or non-invasive ventilation III. major cardiovascular events including stroke, intracranial bleeding, cardiac arrest, myocardial infarction with and without invasive procedure and pulmonary embolism IV. acute renal failure (defined by 2x increase of baseline creatinine or new requirement of dialysis do to volume overload or electrolyte disturbance) V. gastro-intestinal events (hemorrhage, intestinal perforation) | 30 days |
| Decline in functional status of 10% or more | decline in functional status of 10% or more from admission to day 30 measured by the Barthel's index. | 30 days |
| length of in hospital days | Total length of in hospital days 30 days | 30 days |
| 35418509 | Background | Brenton JN, Lehner-Gulotta D, Woolbright E, Banwell B, Bergqvist AGC, Chen S, Coleman R, Conaway M, Goldman MD. Phase II study of ketogenic diets in relapsing multiple sclerosis: safety, tolerability and potential clinical benefits. J Neurol Neurosurg Psychiatry. 2022 Jun;93(6):637-644. doi: 10.1136/jnnp-2022-329074. Epub 2022 Apr 13. |
| 12750536 | Background | FOOD Trial Collaboration. Poor nutritional status on admission predicts poor outcomes after stroke: observational data from the FOOD trial. Stroke. 2003 Jun;34(6):1450-6. doi: 10.1161/01.STR.0000074037.49197.8C. Epub 2003 May 15. |
| 35640017 | Background | Mehta A, De Paola L, Pana TA, Carter B, Soiza RL, Kafri MW, Potter JF, Mamas MA, Myint PK. The relationship between nutritional status at the time of stroke on adverse outcomes: a systematic review and meta-analysis of prospective cohort studies. Nutr Rev. 2022 Nov 7;80(12):2275-2287. doi: 10.1093/nutrit/nuac034. |
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