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The purpose of this study is to determine whether a glaucoma therapy is safe and effective in treating patients with open-angle glaucoma or ocular hypertension.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AL-37807 Suspension | Experimental |
| |
| Xalatan | Active Comparator |
| |
| AL-37807 Vehicle | Placebo Comparator |
| |
| Timolol Maleate | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AL-37807 Ophthalmic Suspension, 1.0% | Drug | One drop in the study eye(s) once daily for 28 days |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mean intra-ocular pressure (IOP) change at Day 28 from baseline (Day 0) | Day 28 |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| United States Investigative Sites in Texas and Other States | Fort Worth | Texas | 76180 | United States |
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| Latanoprost, 0.005% (Xalatan) | Drug | One drop in the study eye(s) once daily for 28 days |
|
|
| AL-37807 Vehicle | Other | One drop in the study eye(s) once daily for 28 days |
|
| Timolol Maleate Ophthalmic Gel Forming Solution, 0.5% | Drug | One drop in the study eye(s) once daily for 28 days |
|
| ID | Term |
|---|---|
| D005902 | Glaucoma, Open-Angle |
| D009798 | Ocular Hypertension |
| D005901 | Glaucoma |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D000077338 | Latanoprost |
| ID | Term |
|---|---|
| D011461 | Prostaglandins F, Synthetic |
| D011465 | Prostaglandins, Synthetic |
| D011453 | Prostaglandins |
| D015777 | Eicosanoids |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |
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