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The purpose of this study is to determine the safety and IOP-lowering ability of a glaucoma therapy in patients with open-angle glaucoma or ocular hypertension.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AL-12182 0.003% | Experimental | One drop in the study eye(s) once daily at approximately 8 a.m. for 14 days |
|
| AL-12182 Solution Vehicle | Placebo Comparator | One drop in the study eye(s) once daily at approximately 8 a.m. for 14 days |
|
| Latanoprost | Active Comparator | One drop in the study eye(s) once daily at approximately 8 a.m. for 14 days |
|
| AL-12182 0.01% | Experimental | One drop in the study eye(s) once daily at approximately 8 a.m. for 14 days |
|
| AL-12182 0.03% | Experimental | One drop in the study eye(s) once daily at approximately 8 a.m. for 14 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AL-12182 0.003% Ophthalmic Solution | Drug | Investigational ophthalmic solution intended for the treatment of open-angle glaucoma or ocular hypertension |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mean Intraocular Pressure (IOP) |
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Inclusion Criteria:
Exclusion Criteria:
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| AL-12182 Ophthalmic Solution Vehicle | Other | Placebo |
|
| Latanoprost 0.005% Ophthalmic Solution | Drug | Commercially marketed ophthalmic solution intended for the treatment of open-angle glaucoma or ocular hypertension |
|
| AL-12182 0.01% Ophthalmic Solution | Drug | Investigational ophthalmic solution intended for the treatment of open-angle glaucoma or ocular hypertension |
|
| AL-12182 0.03% Ophthalmic Solution | Drug | Investigational ophthalmic solution intended for the treatment of open-angle glaucoma or ocular hypertension |
|
| ID | Term |
|---|---|
| D005902 | Glaucoma, Open-Angle |
| D009798 | Ocular Hypertension |
| D005901 | Glaucoma |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| C500274 | AL-12182 |
| D009883 | Ophthalmic Solutions |
| D000077338 | Latanoprost |
| ID | Term |
|---|---|
| D019999 | Pharmaceutical Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D020313 | Specialty Uses of Chemicals |
| D011461 | Prostaglandins F, Synthetic |
| D011465 | Prostaglandins, Synthetic |
| D011453 | Prostaglandins |
| D015777 | Eicosanoids |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |
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