Study Evaluating Desvenlafaxine Succinate Sustained-relea... | NCT00283842

Label	Type	Intervention Names
desvenlafaxine succinate sustained-release (DVS SR) 50mg	Experimental	Drug: DVS SR
desvenlafaxine succinate sustained-release (DVS SR) 100mg	Experimental	Drug: DVS SR
desvenlafaxine succinate sustained-release (DVS SR) 200mg	Experimental	Drug: DVS SR
desvenlafaxine succinate sustained-release (DVS SR) 400mg	Experimental	Drug: DVS SR
Placebo	Placebo Comparator	Drug: Placebo

Name	Type	Description	Arm Group Labels	Other Names
DVS SR	Drug		desvenlafaxine succinate sustained-release (DVS SR) 100mg desvenlafaxine succinate sustained-release (DVS SR) 200mg desvenlafaxine succinate sustained-release (DVS SR) 400mg desvenlafaxine succinate sustained-release (DVS SR) 50mg

Measure	Description	Time Frame
Change in Mean Pain Severity Score From Baseline to 13 Weeks	Pain severity measured on a Numeric Rating Scale (NRS). Range: 0 (no pain) to 10 (worst possible pain). Change: score at 13 weeks minus score at baseline.	Baseline and 13 weeks

Measure	Description	Time Frame
Number of Patients With ≥50% Reduction in Mean Pain Severity Score.	Pain severity measured on a Numeric Rating Scale (NRS). Range: 0 (no pain) to 10 (worst possible pain). Assessment of reduction based on change in score at 13 weeks compared to baseline.	Baseline and 13 weeks

Name	Affiliation	Role
Medical Monitor	Wyeth is now a wholly owned subsidiary of Pfizer	Study Director

PubMed Identifier	Type	Citation	Retractions
25018648	Derived	Allen R, Sharma U, Barlas S. Clinical experience with desvenlafaxine in treatment of pain associated with diabetic peripheral neuropathy. J Pain Res. 2014 Jun 23;7:339-51. doi: 10.2147/JPR.S55682. eCollection 2014.

ID	Title	Description
FG000	Desvenlafaxine Succinate Sustained-release (DVS SR) 50mg	50mg tablets of desvenlafaxine succinate sustained-release (DVS SR) taken orally
FG001	Desvenlafaxine Succinate Sustained-release (DVS SR) 100mg

Other Adverse Events

Term	Organ System	Assessment Type	Statistical Information
Abdominal pain	General disorders	Non-systematic Assessment	EG0003 affected63 at risk EG0012 affected87 at risk EG0021 affected99 at risk EG0031 affected69 at risk EG0041 affected90 at risk
Abscess	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Accidental injury	General disorders	Non-systematic Assessment	EG0003 affected63 at risk EG0015 affected87 at risk EG0027 affected99 at risk EG003
Allergic reaction	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Asthenia	General disorders	Non-systematic Assessment	EG0004 affected63 at risk EG0018 affected87 at risk EG0029 affected99 at risk EG003
Back pain	General disorders	Non-systematic Assessment	EG0002 affected63 at risk EG0010 affected87 at risk EG0023 affected99 at risk EG003
Cellulitis	General disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Chest pain	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0012 affected87 at risk EG0020 affected99 at risk EG003
Chills	General disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0023 affected99 at risk EG003
Cyst	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Face edema	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Fever	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0021 affected99 at risk EG003
Flu syndrome	General disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0013 affected87 at risk EG0021 affected99 at risk EG003
Generalized edema	General disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Headache	General disorders	Non-systematic Assessment	EG0005 affected63 at risk EG0017 affected87 at risk EG0029 affected99 at risk EG003
Infection	General disorders	Non-systematic Assessment	EG0003 affected63 at risk EG0017 affected87 at risk EG0027 affected99 at risk EG003
Malaise	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Medication error	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Mucous membrane disorder	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Neck pain	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Neoplasm	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Overdose	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Pain	General disorders	Non-systematic Assessment	EG0005 affected63 at risk EG0013 affected87 at risk EG0024 affected99 at risk EG003
Photosensitivity reaction	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Withdrawal syndrome	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Angina pectoris	Cardiac disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Arrhythmia	Cardiac disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Atrial flutter	Cardiac disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
AV block first degree	Cardiac disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Bundle branck block	Cardiac disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Cardiovascular physical finding	Cardiac disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Coronary artery disorder	Cardiac disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Electrocardiogram abnormal	Cardiac disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0022 affected99 at risk EG003
Hemorrhage	Vascular disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Hypertension	Vascular disorders	Non-systematic Assessment	EG0002 affected63 at risk EG0016 affected87 at risk EG00211 affected99 at risk EG003
Hypotension	Vascular disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Palpitation	Cardiac disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Peripheral vascular disorder	Vascular disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0022 affected99 at risk EG003
Postural hypotension	Vascular disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0012 affected87 at risk EG0025 affected99 at risk EG003
QRS prolongation	Cardiac disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
QT interval prolonged	Cardiac disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Sinus bradycardia	Cardiac disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Syncope	Cardiac disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Tachycardia	Cardiac disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Vasodilatation	Vascular disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0011 affected87 at risk EG0024 affected99 at risk EG003
Ventricular extrasystoles	Cardiac disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Ventricular tachycardia	Cardiac disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Abdominal distension	Gastrointestinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Anorexia	Gastrointestinal disorders	Non-systematic Assessment	EG0002 affected63 at risk EG0013 affected87 at risk EG0025 affected99 at risk EG003
Colitis	Gastrointestinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Constipation	Gastrointestinal disorders	Non-systematic Assessment	EG0003 affected63 at risk EG0014 affected87 at risk EG0026 affected99 at risk EG003
Diarrhea	Gastrointestinal disorders	Non-systematic Assessment	EG0005 affected63 at risk EG0016 affected87 at risk EG0027 affected99 at risk EG003
Dry mouth	Gastrointestinal disorders	Non-systematic Assessment	EG0002 affected63 at risk EG0014 affected87 at risk EG0025 affected99 at risk EG003
Dyspepsia	Gastrointestinal disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0013 affected87 at risk EG0023 affected99 at risk EG003
Dysphagia	Gastrointestinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Eructation	Gastrointestinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Flatulence	Gastrointestinal disorders	Non-systematic Assessment	EG0002 affected63 at risk EG0012 affected87 at risk EG0020 affected99 at risk EG003
Gastroenteritis	Gastrointestinal disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0011 affected87 at risk EG0022 affected99 at risk EG003
Gastroesophageal reflux disease	Gastrointestinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Gastrointestinal carcinoma	Gastrointestinal disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Gastrointestinal disorder	Gastrointestinal disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Gastrointestinal hemorrhage	Gastrointestinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Hiatal hernia	Gastrointestinal disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Increased appetite	Gastrointestinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Nausea	Gastrointestinal disorders	Non-systematic Assessment	EG0009 affected63 at risk EG00111 affected87 at risk EG00227 affected99 at risk EG003
Periodontal abscess	Gastrointestinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0012 affected87 at risk EG0020 affected99 at risk EG003
Retching	Gastrointestinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Tenesmus	Gastrointestinal disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Tooth disorder	Gastrointestinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Vomiting	Gastrointestinal disorders	Non-systematic Assessment	EG0003 affected63 at risk EG0013 affected87 at risk EG00210 affected99 at risk EG003
Thyroid carcinoma	Endocrine disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Thyroid disorder	Endocrine disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Anemia	Blood and lymphatic system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Ecchymosis	Blood and lymphatic system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Leukopenia	Blood and lymphatic system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Lymphadenopathy	Blood and lymphatic system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Creatinine increased	Metabolism and nutrition disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Gout	Metabolism and nutrition disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Healing abnormal	Metabolism and nutrition disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Hypercholesteremia	Metabolism and nutrition disorders	Non-systematic Assessment	EG0002 affected63 at risk EG0013 affected87 at risk EG0023 affected99 at risk EG003
Hyperglycemia	Metabolism and nutrition disorders	Non-systematic Assessment	EG0002 affected63 at risk EG0011 affected87 at risk EG0021 affected99 at risk EG003
Hyperkalemia	Metabolism and nutrition disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Hyperlipemia	Metabolism and nutrition disorders	Non-systematic Assessment	EG0004 affected63 at risk EG0016 affected87 at risk EG0027 affected99 at risk EG003
Hyperuricemia	Metabolism and nutrition disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Hypoglycemia	Metabolism and nutrition disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Hypokalemia	Metabolism and nutrition disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Hyponatremia	Metabolism and nutrition disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Peripheral edema	Metabolism and nutrition disorders	Non-systematic Assessment	EG0002 affected63 at risk EG0012 affected87 at risk EG0020 affected99 at risk EG003
Weight gain	Metabolism and nutrition disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Weight loss	Metabolism and nutrition disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Arthralgia	Musculoskeletal and connective tissue disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0012 affected87 at risk EG0022 affected99 at risk EG003
Arthritis	Musculoskeletal and connective tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Joint disorder	Musculoskeletal and connective tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Leg cramps	Musculoskeletal and connective tissue disorders	Non-systematic Assessment	EG0004 affected63 at risk EG0013 affected87 at risk EG0023 affected99 at risk EG003
Muscle cramp	Musculoskeletal and connective tissue disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Muscle spasms	Musculoskeletal and connective tissue disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0011 affected87 at risk EG0021 affected99 at risk EG003
Musculoskeletal stiffness	Musculoskeletal and connective tissue disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Myalgia	Musculoskeletal and connective tissue disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0012 affected87 at risk EG0021 affected99 at risk EG003
Myasthenia	Musculoskeletal and connective tissue disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Tendon disorder	Musculoskeletal and connective tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Abnormal dreams	Nervous system disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0012 affected87 at risk EG0023 affected99 at risk EG003
Anxiety	Nervous system disorders	Non-systematic Assessment	EG0003 affected63 at risk EG0010 affected87 at risk EG0023 affected99 at risk EG003
Apathy	Nervous system disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Ataxia	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Carpal tunnel syndrome	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Confusion	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Depersonalization	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0022 affected99 at risk EG003
Depression	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0012 affected87 at risk EG0020 affected99 at risk EG003
Dizziness	Nervous system disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0017 affected87 at risk EG00218 affected99 at risk EG003
Emotional liability	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Euphoria	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Hostility	Nervous system disorders	Non-systematic Assessment	EG0002 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Hyperkinesia	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Hypertonia	Nervous system disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Hypesthesia	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0023 affected99 at risk EG003
Incoordination	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Insomnia	Nervous system disorders	Non-systematic Assessment	EG0003 affected63 at risk EG0011 affected87 at risk EG0024 affected99 at risk EG003
Libido decreased	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0023 affected99 at risk EG003
Memory impairment	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Mental status changes	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Motion sickness	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Movement disorder	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Nervousness	Nervous system disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0011 affected87 at risk EG0023 affected99 at risk EG003
Neuralgia	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Paresthesia	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0022 affected99 at risk EG003
Reflexes decreased	Nervous system disorders	Non-systematic Assessment	EG0002 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Reflexes increased	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Restless legs syndrome	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Somnolence	Nervous system disorders	Non-systematic Assessment	EG0003 affected63 at risk EG0019 affected87 at risk EG0029 affected99 at risk EG003
Thinking abnormal	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Tremor	Nervous system disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0022 affected99 at risk EG003
Twitching	Nervous system disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Vertigo	Nervous system disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0012 affected87 at risk EG0022 affected99 at risk EG003
Bronchitis	Respiratory, thoracic and mediastinal disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Chronic obstructive airways disease	Respiratory, thoracic and mediastinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Cough increased	Respiratory, thoracic and mediastinal disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0014 affected87 at risk EG0021 affected99 at risk EG003
Dyspnea	Respiratory, thoracic and mediastinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0012 affected87 at risk EG0021 affected99 at risk EG003
Epistaxis	Respiratory, thoracic and mediastinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Lung disorder	Respiratory, thoracic and mediastinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0021 affected99 at risk EG003
Nose dryness	Respiratory, thoracic and mediastinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Pharyngitis	Respiratory, thoracic and mediastinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0022 affected99 at risk EG003
Pneumonia	Respiratory, thoracic and mediastinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Pulmonary physical finding	Respiratory, thoracic and mediastinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Rhinitis	Respiratory, thoracic and mediastinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0012 affected87 at risk EG0023 affected99 at risk EG003
Sinusittis	Respiratory, thoracic and mediastinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0013 affected87 at risk EG0024 affected99 at risk EG003
Upper respiratory infection	Respiratory, thoracic and mediastinal disorders	Non-systematic Assessment	EG0002 affected63 at risk EG0013 affected87 at risk EG0022 affected99 at risk EG003
Voice alteration	Respiratory, thoracic and mediastinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Yawn	Respiratory, thoracic and mediastinal disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Acne	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Alopecia	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Contact dermatitis	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Dry skin	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Eczema	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Exfoliative dermatitis	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Folliculitis	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Fungal dermatitis	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Furunculosis	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Herpes simplex	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0002 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Herpes zoster	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Maculopapular rash	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Nail disorder	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Night sweats	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0011 affected87 at risk EG0021 affected99 at risk EG003
Pruritus	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0023 affected99 at risk EG003
Rash	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Seborrhea	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Skin benign neoplasm	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Skin discoloration	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Skin disorder	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0002 affected63 at risk EG0010 affected87 at risk EG0022 affected99 at risk EG003
Skin hypertrophy	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Sweating	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0003 affected63 at risk EG0012 affected87 at risk EG0027 affected99 at risk EG003
Urticaria	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Vesiculobullous rash	Skin and subcutaneous tissue disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Abnormal vision	Eye disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0021 affected99 at risk EG003
Conjunctivitis	Eye disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Ear disorder	Ear and labyrinth disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Ear pain	Ear and labyrinth disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Eye pain	Eye disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Mydriasis	Eye disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Otitis media	Ear and labyrinth disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Refraction disorder	Eye disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Retinal disorder	Eye disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Taste perversion	Ear and labyrinth disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Tinnitus	Ear and labyrinth disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Abnormal ejaculation/orgasm	Reproductive system and breast disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0022 affected99 at risk EG003
Anorgasmia	Reproductive system and breast disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0022 affected99 at risk EG003
Breast disorder	Reproductive system and breast disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Cervix disorder	Reproductive system and breast disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Creatine clearance decreased	Renal and urinary disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Cystitis	Renal and urinary disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Dysuria	Renal and urinary disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0011 affected87 at risk EG0022 affected99 at risk EG003
Hematuria	Renal and urinary disorders	Non-systematic Assessment	EG0003 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Impotence	Renal and urinary disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0014 affected87 at risk EG0022 affected99 at risk EG003
Kidney function abnormal	Renal and urinary disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Nocturia	Renal and urinary disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0021 affected99 at risk EG003
Prostatic disorder	Reproductive system and breast disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0013 affected87 at risk EG0022 affected99 at risk EG003
Prostatic specific antigen increase	Reproductive system and breast disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Pyuria	Renal and urinary disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Sexual function abnormal	Reproductive system and breast disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0012 affected87 at risk EG0021 affected99 at risk EG003
Testis disorder	Reproductive system and breast disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Urinary frequency	Renal and urinary disorders	Non-systematic Assessment	EG0002 affected63 at risk EG0010 affected87 at risk EG0022 affected99 at risk EG003
Urinary hesitation	Renal and urinary disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0021 affected99 at risk EG003
Urinary incontinence	Renal and urinary disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0021 affected99 at risk EG003
Urinary retention	Renal and urinary disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Urinary tract infection	Renal and urinary disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0012 affected87 at risk EG0021 affected99 at risk EG003
Urination impaired	Renal and urinary disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Urine abnormality	Renal and urinary disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0021 affected99 at risk EG003
Vulvovaginal disorder	Reproductive system and breast disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Allergic reaction other than drug	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003
Local reaction to procedure	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Positive event	General disorders	Non-systematic Assessment	EG0000 affected63 at risk EG0011 affected87 at risk EG0020 affected99 at risk EG003
Albuminuria	Renal and urinary disorders	Non-systematic Assessment	EG0001 affected63 at risk EG0010 affected87 at risk EG0020 affected99 at risk EG003

Facility	Status	City	State	ZIP	Country	Contacts
		Mesa	Arizona	85210	United States

ID	Title	Description
BG000	Desvenlafaxine Succinate Sustained-release (DVS SR) 50mg	50mg tablets of desvenlafaxine succinate sustained-release (DVS SR) taken orally
BG001	Desvenlafaxine Succinate Sustained-release (DVS SR) 100mg	100mg tablets of desvenlafaxine succinate sustained-release (DVS SR) taken orally
BG002	Desvenlafaxine Succinate Sustained-release (DVS SR) 200mg	200mg tablets of desvenlafaxine succinate sustained-release (DVS SR) taken orally
BG003	Desvenlafaxine Succinate Sustained-release (DVS SR) 400mg	400mg tablets of desvenlafaxine succinate sustained-release (DVS SR) taken orally
BG004	Placebo
BG005	Total	Total of all reporting groups

ID	Term
D010523	Peripheral Nervous System Diseases
D009468	Neuromuscular Diseases
D009422	Nervous System Diseases
D048909	Diabetes Complications
D003920	Diabetes Mellitus
D004700	Endocrine System Diseases
D009461	Neurologic Manifestations
D012816	Signs and Symptoms
D013568	Pathological Conditions, Signs and Symptoms

ID	Title	Description	Serious Events (Affected)	Other Events (Affected)
EG000	Desvenlafaxine Succinate Sustained-release (DVS SR) 50mg	50mg tablets of desvenlafaxine succinate sustained-release (DVS SR) taken orally	1	47
EG001	Desvenlafaxine Succinate Sustained-release (DVS SR) 100mg	100mg tablets of desvenlafaxine succinate sustained-release (DVS SR) taken orally	1	65
EG002	Desvenlafaxine Succinate Sustained-release (DVS SR) 200mg	200mg tablets of desvenlafaxine succinate sustained-release (DVS SR) taken orally	1	82
EG003	Desvenlafaxine Succinate Sustained-release (DVS SR) 400mg	400mg tablets of desvenlafaxine succinate sustained-release (DVS SR) taken orally	3	63
EG004	Placebo		6	68