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The objectives of this study is:
Iron deficiency anaemia is a common denominator for both schistosomiasis and soil transmitted helminths. Iron deficiency appears to affect the immune response against schistosomes and intestinal helminths. It therefore follows that correcting the iron deficiency anaemia will improve the efficacy of anthelminthics such as praziquantel (against schistosomiasis) and albendazol (against soil transmitted helminths) and ability of the host immune system to resist reinfection with schistosomes and soil transmitted helminths.
The aim of this study is to identify factors necessary for a successful weekly iron supplementation programme in schistosomiasis and soil transmitted helminths control programmes. In addition impact of weekly iron supplementation programme n haemoglobin levels, efficacy of praziquantel, and schistosomiasis re-infection will be studied.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ferrous sulphate (drug) | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Urine samples examined for schistsoma haematobium at month 0, 3. 6 and 9 | ||
| Stool samples examined for schistsoma mansoni at mont 0, 3, 6 and 9 | ||
| Blood samples examined for haemoglobin level mont 0 and month 9 |
| Measure | Description | Time Frame |
|---|---|---|
| Any side effects to iron supplementation, measured every week for the first foru weeks after treatment start. Mesured on: | ||
| - headache | ||
| nausea |
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Inclusion Criteria:all schoolchildren, in grade 2 and 3, at four selected schools -
Exclusion Criteria:
-
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| Name | Affiliation | Role |
|---|---|---|
| Victor Mwanakasale, Ph.d.,M.Sc. | Tropical Disease Research Centre, Ndola, Zambia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kenani and Chandwe School | Kenani | Nchelenge district | Zambia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19780472 | Derived | Mwanakasale V, Siziya S, Mwansa J, Koukounari A, Fenwick A. Impact of iron supplementation on schistosomiasis control in Zambian school children in a highly endemic area. Malawi Med J. 2009 Mar;21(1):12-8. doi: 10.4314/mmj.v21i1.10982. |
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| ID | Term |
|---|---|
| D012552 | Schistosomiasis |
| D006373 | Helminthiasis |
| D000740 | Anemia |
| ID | Term |
|---|---|
| D014201 | Trematode Infections |
| D010272 | Parasitic Diseases |
| D007239 | Infections |
| D000079426 | Vector Borne Diseases |
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| ID | Term |
|---|---|
| C020748 | ferrous sulfate |
| D004364 | Pharmaceutical Preparations |
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| vomiting |
| body weakness |
| diarrhoea |
| abdominal pain |
| others |
| D006402 |
| Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |