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Atrial fibrillation (AF), which is the name for rapid beats in the upper chambers of the heart, is the world's most common kind of irregular heart beat. People with AF experience symptoms such as heart palpitations (a racing or pounding feeling in the chest), shortness of breath, dizziness, fatigue or weakness. Although AF can occur in otherwise healthy people for no apparent reason, it is sometimes associated with high blood pressure, heart disease or lung problems. The purpose of the SAFARI trial is to study the effectiveness of pacing algorithms in the upper chamber of the heart for patients who have both AF and bradycardia (slow heart beat).
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pacing Algorithms | Device |
| Measure | Description | Time Frame |
|---|---|---|
| Safety/Efficacy |
| Measure | Description | Time Frame |
|---|---|---|
| Various |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Not Required For IDE Studies |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yuma | Arizona | United States | ||||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16875902 | Background | Gold MR, Hoffmann E; SAFARI Investigators. Rationale and design of a randomized clinical trial to assess the role of overdrive and triggered prevention pacing therapies in reducing atrial fibrillation: the Study of Atrial Fibrillation Reduction (SAFARI). Am Heart J. 2006 Aug;152(2):231-6. doi: 10.1016/j.ahj.2005.11.012. |
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| Fayetteville |
| Arkansas |
| United States |
| Fort Smith | Arkansas | United States |
| Bakersfield | California | United States |
| Berkeley | California | United States |
| Los Angeles | California | United States |
| Aurora | Colorado | United States |
| Stamford | Connecticut | United States |
| Clearwater | Florida | United States |
| Daytona Beach | Florida | United States |
| Ormond Beach | Florida | United States |
| Tampa | Florida | United States |
| Atlanta | Georgia | United States |
| Chicago | Illinois | United States |
| Lombard | Illinois | United States |
| Springfield | Illinois | United States |
| Shreveport | Louisiana | United States |
| Brighton | Massachusetts | United States |
| Lansing | Michigan | United States |
| Saint Paul | Minnesota | United States |
| Paterson | New Jersey | United States |
| Ridgewood | New Jersey | United States |
| East Syracuse | New York | United States |
| Rochester | New York | United States |
| Syracuse | New York | United States |
| Cincinnati | Ohio | United States |
| Cleveland | Ohio | United States |
| Columbus | Ohio | United States |
| Elyria | Ohio | United States |
| Pittsburgh | Pennsylvania | United States |
| Charleston | South Carolina | United States |
| Nashville | Tennessee | United States |
| Dallas | Texas | United States |
| Houston | Texas | United States |
| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| D001919 | Bradycardia |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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