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| Name | Class |
|---|---|
| Merck Sharp & Dohme LLC | INDUSTRY |
| National Cheng-Kung University Hospital | OTHER |
| National Taiwan University Hospital | OTHER |
To determine the cumulative incidence of total hip replacement, time to event after treatment with Fosamax or placebo during the study peroid
To determine the cumulative incidence of total hip replacement and collpase of femoral head, time to event after treatment with Fosamax or placebo during the study peroid
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Alendronate | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| the cumulative of total hip replacement |
| Measure | Description | Time Frame |
|---|---|---|
| necrotic area | ||
| Harris hip score |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gwo-Jaw Wang, MD | Kaohsiung Medical University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung City | 807 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16203877 | Background | Lai KA, Shen WJ, Yang CY, Shao CJ, Hsu JT, Lin RM. The use of alendronate to prevent early collapse of the femoral head in patients with nontraumatic osteonecrosis. A randomized clinical study. J Bone Joint Surg Am. 2005 Oct;87(10):2155-9. doi: 10.2106/JBJS.D.02959. | |
| 22127729 | Derived | Chen CH, Chang JK, Lai KA, Hou SM, Chang CH, Wang GJ. Alendronate in the prevention of collapse of the femoral head in nontraumatic osteonecrosis: a two-year multicenter, prospective, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2012 May;64(5):1572-8. doi: 10.1002/art.33498. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | May 4, 2015 | |
| Reset | May 19, 2015 | |
| Release | Mar 15, 2017 | |
| Reset | Apr 26, 2017 | |
| Release | Jun 11, 2017 | |
| Reset | Feb 1, 2018 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 4, 2015 | May 19, 2015 | |||
| Mar 15, 2017 |
| ID | Term |
|---|---|
| D010020 | Osteonecrosis |
| ID | Term |
|---|---|
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D009336 | Necrosis |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D019386 | Alendronate |
| ID | Term |
|---|---|
| D004164 | Diphosphonates |
| D063065 | Organophosphonates |
| D009943 | Organophosphorus Compounds |
| D009930 | Organic Chemicals |
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| Apr 26, 2017 |
| Jun 11, 2017 | Feb 1, 2018 |
| D013568 |
| Pathological Conditions, Signs and Symptoms |