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The purpose of this study is to determine the duration of the treatment with alendronate in postmenopausal women with osteoporosis.
The duration of the treatment with alendronate is not well established. The investigators recruited 228 women with postmenopausal osteoporosis. They all received alendronate during the first 3 years of monitoring and were later on randomized to whether different regimens of intermittent treatment or to carry on 3 years more.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| alendronate 6 years | Experimental |
| |
| alendronate 5 years | Experimental | No treatment during year 6th |
|
| alendronate 5 years, not continued | Experimental | No treatment during year 5th |
|
| alendronate 4 years | Experimental | No treatment during year 5th and 6th |
|
| alendronate 5 years, uncontinued | Experimental | No treatment during year 4th |
|
| alendronate 4 years, not continued | Experimental | No treatment during year 4th and 6th |
|
| alendronate 4 years, uncontinued |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| alendronate | Drug | several duration of treatment |
|
| Measure | Description | Time Frame |
|---|---|---|
| Bone mineral density | Every year |
| Measure | Description | Time Frame |
|---|---|---|
| Fractures | Every year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Carlos Lozano Tonkin, doctor | university san carlos hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University San Carlos Hospital | Madrid | Madrid | 28040 | Spain |
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| ID | Term |
|---|---|
| D010024 | Osteoporosis |
| ID | Term |
|---|---|
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D019386 | Alendronate |
| ID | Term |
|---|---|
| D004164 | Diphosphonates |
| D063065 | Organophosphonates |
| D009943 | Organophosphorus Compounds |
| D009930 | Organic Chemicals |
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| Experimental |
No treatment during year 4th and 5th |
|
| Alendronato 3 years | Experimental | No treatment during the last 3 years |
|
|
| D009750 |
| Nutritional and Metabolic Diseases |