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| ID | Type | Description | Link |
|---|---|---|---|
| Can Diabetes Assoc Grant 1323 | |||
| CIHR Grant OOP-64648 |
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| Name | Class |
|---|---|
| Canadian Diabetes Association | OTHER |
| Canadian Institutes of Health Research (CIHR) | OTHER_GOV |
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High intake of cereal fibre has been shown to be associated with reduced weight gain and improved insulin sensitivity. We hypothesize these effects are due to the short chain fatty acids derived from the bacterial fermentation (breakdown) of fibre in the colon (large intestine). Insulin resistant subjects will be randomized to receive 2 servings of a low-fibre cereal (eg. puffed rice) or 2 servings of a high-fibre cereal (wheat bran cereal) per day for one year. The effects of the diets on body weight, appetite, abdominal fat, blood short chain fatty acids, glucose, insulin, lipids and hormones will be measured
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low fibre breakfast cereal (puffed rice/cornflakes) | Drug | |||
| High fibre cereal (All Bran/Bran Flakes) | Drug |
| Measure | Description | Time Frame |
|---|---|---|
| Serum acetate concentration | 0, 3, 6, 9 and 12 months | |
| Serum butyrate concentration | 0, 3, 6, 9 and 12 months | |
| Plasma GLP-1 concentration | 0, 3, 6, 9 and 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Fasting glucose and insulin | 0, 3, 6, 9 and 12 months | |
| HOMA insulin resistance and beta cell function | 0, 3, 6, 9 and 12 months | |
| postprandial glucose and insulin |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Thomas MS Wolever, BM, BCh, PhD, DM | University of Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St. Michael's Hospital | Toronto | Ontario | M5B 1W8 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19664300 | Result | Freeland KR, Wilson C, Wolever TM. Adaptation of colonic fermentation and glucagon-like peptide-1 secretion with increased wheat fibre intake for 1 year in hyperinsulinaemic human subjects. Br J Nutr. 2010 Jan;103(1):82-90. doi: 10.1017/S0007114509991462. Epub 2009 Aug 7. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D003920 | Diabetes Mellitus |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| 0, 3, 6, 9 and 12 months |
| Body weight | 0, 3, 6, 9 and 12 months |
| waist circumference | 0, 3, 6, 9 and 12 months |
| Abdominal fat | 0 and 12 months |
| food intake | 0, 3, 6, 9 and 12 months |
| Fasting lipids (cholesterol, triglyceride, HDL, LDL) | 0, 3, 6, 9 and 12 months |
| Fasting and postprandial free fatty acids and triglycerides | 0, 3, 6, 9 and 12 months |
| Fasting and postprandial c-peptide | 0, 3, 6, 9 and 12 months |
| C-peptide/insulin ratio as marker of hepatic insulin extraction | 0, 3, 6, 9 and 12 months |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D006946 | Hyperinsulinism |