Effects of Nutritional Supplementation on Protein and Energy Homeostasis in Malnourished Chronic Hemodialysis Patients

Effects of Nutritional Supplementation on Protein and Energy Homeostasis in Malnourished Chronic Hemodialysis Patients

The goal of this study is to evaluate the metabolic effects of concomitant use of three consecutive doses of recombinant human growth hormone over three days and exercise during continuous nutrient infusion in chronic hemodialysis patients. We would also like to evaluate the metabolic effects of nutritional supplementation alone without the additional anabolic strategies.

Inclusion Criteria:

• On hemodialysis for more than 6 months, on a thrice weekly hemodialysis program;
• Adequately dialyzed (Kt/V > 1.4).

Exclusion Criteria:

• Patients unable to perform exercise.
• Pregnant women.
• Severe unstable underlying disease besides commonly associated with ESRD. Cardiac patients that are stable will be included.
• Patients hospitalized within the last month prior to the study.
• Patients with recirculation detected on the AV graft.
• Patients receiving steroids and/or other immunosuppressive agents