Dose Effects of Hormone Therapy (Two Doses of Estradiol Associated to Progesterone) on Inflammatory Markers

Pro-Inflammatory Effects of Two Different Doses of 17 Beta Estradiol in Menopausal Women

Primary purpose : Effects of two doses of hormone therapy on hsCRP. The effects of hormone replacement therapy on inflammatory markers are dose-dependent.

Pro-inflammatory study of the effects in short term of two difference doses of 17beta-estradiol at the menopause woman

Inclusion Criteria:

• Symptomatic menopausal women : >=50 years and amenorrhea >=1 year or <50 years and amenorrhea >=1 year and plasmatic FSH >= 30 UI/l
• Normal mammography in the last 2 years before inclusion
• Normal cervical smear in the last 2 years before inclusion
• Written consent for participation in the study

Exclusion Criteria:

• Unconfirmed Menopause with amenorrhoea of less than year
• Oestrogen-progesterone Treatment anterior in 3 months previous the inclusion
• Recently a viral Infection or bacteriologic(at least of 2 weeks)
• Dental Infection
• Inflammatory Pathology chronicles
• Antecedent of pathology cancerous with or no a sly hemopathy
• Addiction to smoking of more than 20 cigarettes a day or an alcoholic consumption furthermore of 4 glasses a day
• Taken concomitant of one of the treatments forbidden:statine, vitamin B6 or B12, folates, antiinflammatory, anti aggregant Plaquettes, DHEA, phytoestrogens
• Refusal to sign the assent informed
• Not membership in a regime about social security