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The purpose of this study is to examine the precision, bias and limits of agreement when monitoring the neuromuscular block with acceleromyography with and without preload and compare the method to the gold standard, mechanomyography.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Active Comparator | Acceleromyography with Hand Adapter on dominant arm |
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| 2 | Active Comparator | Acceleromyography with Hand Adapter on non-dominant arm |
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| 3 | Placebo Comparator | Acceleromyography without Hand Adapter on dominant arm |
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| 4 | Placebo Comparator | Acceleromygraphy without Hand Adapter on non-dominant arm |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hand Adapter (Organon, Oss, the Netherlands) | Device | Randomization of acceleromyography with or without Hand Adapter to dominant or non-dominant arm. Contralateral neuromuscular transmission is measured with mechanomyography (The gold standard of neuromuscular monitoring) |
| Measure | Description | Time Frame |
|---|---|---|
| The precision of acceleromyography with and without preload during recovery |
| Measure | Description | Time Frame |
|---|---|---|
| Bias and limits of agreement for acceleromyography (AMG) with and without preload compared to mechanomyography (MMG) during recovery | ||
| All the following outcomes obtained with AMG with and without preload are compared to MMG. Furthermore the responses are compared when the AMG-values are "normalized": |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Casper C Kjaer, MD | Rigshospitalet, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dep. of anesthesia, HOC, Rigshospitalet | Copenhagen | Copenhagen Ø | 2100 | Denmark |
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| Placebo | Device | placebo |
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| Bias og limits of agreement between control TOF |
| Onset time |
| Time to reappearance of T1, T2, T3 and T4 |
| Twitch height of T1 at reappearance of T1, T2, T3 and T4 |
| Time to T1=25% |
| Interval 25-75% |
| Time to TOF-ratio = 0.9 and 1.0 |
| Time to final T1 |
| Time to final TOF ratio |