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| ID | Type | Description | Link |
|---|---|---|---|
| NIDDK R21 DK57053 | |||
| ACG Research Award 2000-2001 |
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inadequate number of patients, study completed with normal subjects
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| Name | Class |
|---|---|
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | NIH |
| American College of Gastroenterology | OTHER |
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The hypothesis of the study is that women perceive intestinal stimulation (rectal balloon distention) differently in different phases of the menstrual cycle, i.e there is an effect of hormones on the sensory pathway, and that this difference is reflected in the Central Nervous System processing of this signal. We also hypothesize that there is a difference in perception between control subjects and subjects with the irritable bowel syndrome.
There is discrepancy in the literature concerning the effect of the menstrual cycle on bowel function and pain syndromes such at irritable bowel syndrome. In addition, recent studies indicate a difference in the CNS processing of rectal stimulation in normal subjects and patients with IBS. This study will determine the differences in the perception of rectal balloon distention in the follicular and luteal phases of the menstrual cycle, in control subjects with no bowel symptoms and volunteers with IBS, and will compare the CNS processing of this signal using functional MRI , again in the two phases of the menstrual cycle.
Comparisons: between control subjects without GI symptoms and those with irritable bowel syndrome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | subjects with no irritable bowel syndrome or gastrointestinal complaints and regular menstrual cycle. |
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| IBS | women with IBS symptoms and normal menstrual cycle. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| perception of rectal balloon distention | Behavioral | functional Magnetic Resonance Imaging (fMRI) study with measurement of brain MRI response to rectal balloon distention. |
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| Measure | Description | Time Frame |
|---|---|---|
| Sensitivity to rectal distention | pressure at which certain sensations are felt when barostat is inflated in the rectum during follicular and luteal phase of menstrual cycle | during the study period only |
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Inclusion Criteria:
Exclusion Criteria:
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women with menstrual cycle
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| Name | Affiliation | Role |
|---|---|---|
| Ann Ouyang, MD | Penn State College of Medicine and Penn State Milton S. Hershey Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hershey Medical Center | Hershey | Pennsylvania | 17033 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Background | Wrzos HF, Li Q, Ouyang A. Visceral and somatic pain thresholds in healthy and IBS volunteers across the menstrual cycle. The American Journal of Gastroenterology 98: S265, 2003 |
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| ID | Term |
|---|---|
| D043183 | Irritable Bowel Syndrome |
| D001008 | Anxiety Disorders |
| ID | Term |
|---|---|
| D003109 | Colonic Diseases, Functional |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
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| D004066 | Digestive System Diseases |
| D001523 | Mental Disorders |