Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy

To test the current standard of care (SOC) treatment for laparoscopic cholecystectomy with a group receiving SOC + additional perioperative analgesics in terms of postoperative abilities, PONV, pain and discharge time from the PACU

Aim of the study: to compare postoperative complaints (PONV, pain, etc) and PACU discharge time between two groups:

• A: standard of care (SOC)receiving intraoperative dexamethasone, ondansetron, ketorolac, and general anaesthesia with propofol, remifentanil and cisatracurium
• B: SOC + preoperative gabapentin, intraoperative lidocain infusion, s-ketamin and droperidol.

Primary endpoints:

• postoperative abilities over time
• discharge time from PACU according to fixed criteria
• consumption of analgesics and antiemetics in the PACU

Secondary endpoints:

• degree of nursing requirements at the PACU
• General tolerability of the regimes

Inclusion Criteria:

• Elective laparoscopic cholecystectomy
• Age above 18 years
• Written informed consent
• ASA class I-III

Exclusion Criteria:

• Planned abdominal cholecystectomy
• Intraoperative conversion of laparoscopic to laparotomic cholecystectomy
• Allergy to part of the treatment regimens
• Previous reactions to opioids (nausea, cognition)