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| Name | Class |
|---|---|
| Heart and Stroke Foundation of Canada | OTHER |
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The purpose of our study is to use a flaxseed-based nutritional supplement in combination with exercise training (walking) for improving cholesterol levels. We hypothesize that exercise training will improve cholesterol profile and that adding supplementation with a flaxseed nutritional supplement will further improve cholesterol profile.
Flax supplementation and exercise training each have small beneficial effects for improving blood lipid profile and reducing cardiovascular disease risk. Flax lignan, a phytoestrogen found in flaxseed is thought to be the active compound responsible for the cholesterol-lowering effect of flaxseed. Our purpose is to combine an exercise training program (walking) with flax lignan supplementation for improving blood lipid profile.
Comparisons: Walking (6 days per week) plus flax lignan (500 mg per day) compared to walking plus placebo.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | flax lignan |
|
| 2 | Placebo Comparator | placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Flax lignan | Dietary Supplement | 543 mg SDG per day |
|
| Measure | Description | Time Frame |
|---|---|---|
| metabolic syndrome score | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Total cholesterol at 2, 4, and 6 months | 6 months | |
| High density lipoprotein at 2, 4, and 6 months | 6 months | |
| Low density lipoprotein at 2, 4, and 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Philip D Chilibeck, PhD | University of Saskatchewan | Principal Investigator |
| H J Biem, MD | University of Saskatchewan | Study Director |
| Lisa Paus-Jenssen, MD | University of Saskatchewan | Study Director |
| Susan Whiting, PhD | University of Saskatchewan | Study Director |
| Punam Pahwa, PhD | University of Saskatchewan | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Saskatchewan | Saskatoon | Saskatchewan | S7N 5B2 | Canada |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| D010024 | Osteoporosis |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D016138 | Walking |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Exercise (walking) | Behavioral | walking 45 minutes per day 5 days per week |
|
| 6 months |
| Triglycerides at 2, 4, and 6 months | 6 months |
| Blood glucose at 2, 4, and 6 months | 6 months |
| Body composition at 6 months | 6 months |
| Aerobic fitness at 6 months | 6 months |
| Waist Girth at 6 months | 6 months |
| Body mass index at 6 months | 6 months |
| Lumbar spine bone mineral density at 6 months | 6 months |
| Proximal femur bone mineral density at 6 months | 6 months |
| Whole body bone mineral density at 6 months | 6 months |
| Trunk fat skinfolds at 6 months | 6 months |
| inflammatory cytokines | 6 months |
| D009750 |
| Nutritional and Metabolic Diseases |
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D001519 | Behavior |
| D008124 | Locomotion |