Efficacy and Safety of Ivabradine on Top of Atenolol in Stable Angina Pectoris

Evaluation of the Anti-anginal Efficacy and Safety of Oral Administration of Ivabradine Compared to Placebo on Top of Background Therapy With Atenolol in Patients With Stable Angina Pectoris. A Four-month Randomised Double-blind, Parallel Group International Multicentre Study.

To test whether ivabradine when given in combination with atenolol is able to improve the exercise tolerance of patients with stable angina pectoris

Inclusion Criteria:

• Chronic stable angina pectoris
• Documented coronary artery disease
• Previous treatment with atenolol or other beta-blocker agent
• Exercise tolerance test positivity and stability

Exclusion Criteria:

• Heart rate < 60 bpm
• Congestive heart failure