Switching to Duloxetine From Other Antidepressants

Switching to Duloxetine From Other Antidepressants: A Regional Multicentre Trial Comparing Two Switching Techniques

A multicentre, randomised, open label study of out-patients with major depression who have failed to respond adequately to antidepressant treatment for their current episode of depression. The study compares outcomes associated with two methods of switching from current antidepressant to duloxetine

Inclusion Criteria:

• Male and female outpatients of at least 18 years of age, who meet criteria for Major Depressive Disorder (MDD)
• Currently non- or only partially-responsive to an SSRI antidepressant after at least 5 weeks of treatment

Exclusion Criteria include:

• Current primary Axis I disorder other than MDD
• Previous diagnosis of bipolar disorder, schizophrenia, or other psychotic disorders
• Patients judged to be at serious suicidal risk.
• Serious medical illness