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The purpose of this study is to evaluate whether adding AF Suppressionâ„¢ to cardiac resynchronization therapy (CRT) improves the prognosis of heart failure patients benefiting from cardiac resynchronization therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | CRT + AF Suppression turned ON |
|
| 2 | Active Comparator | CRT + AF Suppression turned OFF |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Atrial Overdrive Pacing | Device | Pacemaker/ ICD implant |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of permanent atrial fibrillation | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
Unstable angina or acute myocardial infarction (MI) (< 3 months)
Coronary artery bypass grafting (CABG) or percutaneous transluminal coronary angioplasty (PTCA) < 3 months
Life expectancy < 6 months
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| Name | Affiliation | Role |
|---|---|---|
| Luigi Padeletti, MD | Ospedale Carregi, Firenze, Italy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinica Medica Generale e Cardiologia - Ospedale Careggi | Florence | 50134 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15450280 | Background | Padeletti L, Musilli N, Porciani MC, Colella A, Di Biase L, Ricciardi G, Pieragnoli P, Michelucci A, Gensini G. Atrial fibrillation and cardiac resynchronization therapy: the MASCOT study. Europace. 2004 Sep;5 Suppl 1:S49-54. doi: 10.1016/j.eupc.2004.07.007. | |
| 18760135 | Derived | Padeletti L, Muto C, Maounis T, Schuchert A, Bongiorni MG, Frank R, Vesterlund T, Brachmann J, Vicentini A, Jauvert G, Tadeo G, Gras D, Lisi F, Dello Russo A, Rey JL, Boulogne E, Ricciardi G; Management of Atrial fibrillation Suppression in AF-HF COmorbidity Therapy Study Group. Atrial fibrillation in recipients of cardiac resynchronization therapy device: 1-year results of the randomized MASCOT trial. Am Heart J. 2008 Sep;156(3):520-6. doi: 10.1016/j.ahj.2008.04.013. Epub 2008 Jul 7. |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D001281 | Atrial Fibrillation |
| D018754 | Ventricular Dysfunction |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001145 | Arrhythmias, Cardiac |
| D010335 | Pathologic Processes |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |