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| Name | Class |
|---|---|
| Queen's University, Kingston, Ontario | OTHER |
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To compare antidepressant efficacy of left or right to sham Repetitive Transcranial Magnetic Stimulation (rTMS)
to determine if non-responders can become responders if treated on the other side of the hemisphere
(rTMS)
Patients will be assigned to one of 3 treatment arms for 10 days of treatment with either left high frequency or right high frequency, or sham rTMS. After 10 days of treatment, and no improvement, another 10 days of treatment follows, this time with the coil placed on the other hemisphere. Subjects will be followed for 2 months respectively with unrestricted treatment provided by their regular physician. Mood stabilizers will be continued throughout this trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1, Phase l, True or Sham | Sham Comparator | this treatment will be True or Sham (placebo) on one side of the head, phase I |
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| 2, phase ll, Sham or True | Active Comparator | This treatment will be Sham(placebo)or True on the other side of the head phase II. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Magnetic Stimulation (TMS) | Device | Phase l clients receive either True or Sham TMS treatments on left or right side of head for 10 days. Phase ll clients will receive either Sham or True TMS treatments on the other side of the head - the same type as in phase l - |
| Measure | Description | Time Frame |
|---|---|---|
| To compare antidepressant efficacy of right, left to sham | within 9 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| To determine if QEEG activity correlates with antidepressant response to rTMS | within 9 weeks | |
| To determine if non-responders can become responders if treating the opposite hemisphere | within 9 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gary Hasey, MD | McMaster University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St. Joseph's Healthcare, rTMS Laboratory, Mood Disorder Program, 100 West Fifth Street | Hamilton | Ontario | L8N 3K7 | Canada |
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| ID | Term |
|---|---|
| D001714 | Bipolar Disorder |
| ID | Term |
|---|---|
| D000068105 | Bipolar and Related Disorders |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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