Pharmacokinetics of Curcumin in Healthy Volunteers

Evaluation of Naturally Occurring Inhibitors of UDP-glucuronyltransferase on the Oral Bioavailability of Curcumin in Normal Healthy Volunteers

This study looks to describe the pharmacokinetics of curcumin delivered as a single oral dose in healthy female volunteers. The impact of piperine and silybin on the pharmacokinetics of curcumin is also studied.

Healthy volunteers are seen on three separate visits and receive 4 gm of curcumin as a single oral dose either alone or with piperine or with silybin. Serial timed blood draws then are collected for pharmacokinetic analysis.

Inclusion Criteria:

• Healthy volunteer
• On no medications except for birth control pills
• Signed informed consent

Exclusion Criteria:

• Pregnant
• Comorbid disease