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| ID | Type | Description | Link |
|---|---|---|---|
| W81XWH-16-C-0031 | Other Grant/Funding Number | Department of Defense | |
| CTN16-2020(RG) | Other Identifier | NACTN |
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| Name | Class |
|---|---|
| Christopher Reeve Paralysis Foundation | OTHER |
| The Methodist Hospital Research Institute | OTHER |
| The University of Texas Health Science Center, Houston | OTHER |
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The NACTN Spinal Cord Injury Registry is a network of clinical centers collecting de-identified data from patients admitted through the Emergency Department of a NACTN center at the time of injury with an initial (first time) spinal cord injury (SCI). Information will be collected on the natural history of SCI and course of treatment through the first 12 months from the date of injury or long as medically indicated. Data collected includes imaging information from CT or MRI scans, neurological and general medical outcome and rehabilitation evaluation. No intervention is given other than standard of care for spinal cord injury, intensive monitoring and frequent follow up care.
The participating centers include:
University of Texas Health Science Center, Houston; University of Toronto, Toronto; University of Virginia, Charlottesville; University of Louisville, Louisville; University of Maryland, Baltimore; Walter Reed National Military Medical Center, Bethesda; Thomas Jefferson University, Philadelphia; University of Miami, Miami; Brooke Army Medical Center, Fort Sam Houston; Louisiana State University Health Sciences Center, New Orleans; Vanderbilt University Medical Center, Nashville; Medical College Wisconsin, Milwaukee; Duke University, Durham
The NACTN Clinical Coordinating Center is located at:
Houston Methodist Hospital, Houston
The Center for Biostatistics is located at:
Houston Methodist Hospital, Houston
The Data Management Center is located at:
University of Louisville, Louisville
Preliminary work has been completed on the selection of data elements, data collection protocols, case record form design, and the design of a computer system for clinical data management and data quality control.
In the first phase of the network, data will be collected on the natural history of SCI. Although there is considerable data in the literature about the natural history of SCI, current changes in treatment appear to be modifying the natural history. In particular very early surgery, including decompression of the spinal cord and vertebral stabilization with instrumentation appears, in some cases of SCI, to be improving outcomes.
No treatment is given other than standard of care for SCI. Data is collected in hopes to help SCI patients in the future.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No Treatment Given | Any male or female 18 years or older admitted to a NACTN hospital, at the time of injury, with an initial (first time) spinal cord injury caused by trauma and has paralysis (muscle weakness) or loss of sensation (touch). The patient has not received medical or surgical care for this injury prior to admission to a NACTN hospital. Patient or family member must give consent to participate. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No Treatment Given | Other | Intervention is not given. |
|
| Measure | Description | Time Frame |
|---|---|---|
| International Standards For Neurological Classification of Spinal Injury (ISNCSCI) | A neurological assessment and classification of a spinal cord injury | Pre-operative, Post-operative, 2 weeks, Discharge, 3 months, 6 months, 12 months, 36 months and 48 months |
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Inclusion Criteria:
Exclusion Criteria:
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Admitted to a NACTN hospital through the Emergency Department at the time of injury.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Elizabeth G Toups, MSN, RN, CCRP | Contact | 832-722-4055 | etoups@houstonmethodist.org | |
| Tanisha Bernhardt | Contact | 713-441-3814 |
| Name | Affiliation | Role |
|---|---|---|
| Robert G Grossman, MD | Houston Methodist Hospital, Houston | Study Chair |
| Karl M Schmitt, MD | The University of Texas, Houston | Principal Investigator |
| Michael G Fehlings, MD, PhD |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Miami | Recruiting | Miami | Florida | 33136 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37607093 | Derived | Bak AB, Moghaddamjou A, Harrop JS, Aarabi B, Fehlings MG. The Impact of Interhospital Transfer on the Extent of Neurological Recovery in Acute Traumatic Spinal Cord Injury: Analysis of a Prospective Multicenter Data Set in 970 Cases. Neurosurgery. 2024 Jan 1;94(1):90-98. doi: 10.1227/neu.0000000000002642. Epub 2023 Aug 21. |
| Label | URL |
|---|---|
| NACTN's Background, Mission, Sites and Resources | View source |
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| University of Virginia |
| OTHER |
| University of Louisville | OTHER |
| University of Toronto | OTHER |
| University of Maryland, Baltimore | OTHER |
| Walter Reed National Military Medical Center | FED |
| Thomas Jefferson University | OTHER |
| University of Miami | OTHER |
| Brooke Army Medical Center | FED |
| Louisiana State University Health Sciences Center in New Orleans | OTHER |
| Vanderbilt University Medical Center | OTHER |
| Medical College of Wisconsin | OTHER |
| Duke University | OTHER |
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| University of Toronto/Toronto Western Hospital, Toronto |
| Principal Investigator |
| Emily Sieg, MD | University of Louisville, Louisville | Principal Investigator |
| Bizhan Aarabi, MD | University of Maryland Medical Center, Baltimore Shock Trauma Center | Principal Investigator |
| Chun-Po Yen, MD | University of Virginia Health System, Charlottesville | Principal Investigator |
| Christopher J Neal, MD | Walter Reed National Military Medical Center, Bethesda | Principal Investigator |
| James S Harrop, MD | Thomas Jefferson University, Philadelphia | Principal Investigator |
| James D Guest, MD, PhD | University of Miami, Miami | Principal Investigator |
| Ryan P Morton, MD | Brooke Army Medical Center, Fort Sam Houston | Principal Investigator |
| Jason D Wilson, MD | Louisiana State University Health Sciences Center in New Orleans | Principal Investigator |
| Hamid Shah, MD | Vanderbilt University Medical Center, Nashville | Principal Investigator |
| Shekar N Kurpad, MD, PhD | Medical College of Wisconsin, Milwaukee | Principal Investigator |
| Christopher I Shaffrey, MD | Duke University, Durham | Principal Investigator |
| University of Louisville Health Sciences Center | Active, not recruiting | Louisville | Kentucky | 40205 | United States |
| Louisiana State University Medical Sciences Center in New Orleans | Recruiting | New Orleans | Louisiana | 70112 | United States |
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| University of Maryland Medical Center | Recruiting | Baltimore | Maryland | 21201 | United States |
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| Walter Reed National Military Medical Center | Recruiting | Bethesda | Maryland | 20889 | United States |
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| Duke University | Not yet recruiting | Durham | North Carolina | 27710 | United States |
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| Thomas Jefferson University | Recruiting | Philadelphia | Pennsylvania | 19107 | United States |
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| Hamid Shah, MD | Not yet recruiting | Nashville | Tennessee | 37240 | United States |
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| Brooke Army Medical Center | Active, not recruiting | Fort Sam Houston | Texas | 78234 | United States |
| Houston Methodist Hospital | Active, not recruiting | Houston | Texas | 77030 | United States |
| The University of Texas, Houston | Recruiting | Houston | Texas | 77030 | United States |
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| University of Virginia Health System | Recruiting | Charlottesville | Virginia | 22903 | United States |
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| Medical College of Wisconsin | Not yet recruiting | Milwaukee | Wisconsin | 53226 | United States |
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| University of Toronto/Toronto Western Hospital | Recruiting | Toronto | Ontario | M5T-2S8 | Canada |
|
| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| D010243 | Paralysis |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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