Active Vitamin D Effect on Left Ventricular Hypertrophy

The Efficacy of 1,25 Dihydroxycholecalciferol on the Cardiovascular System in Patients With Renal Dysfunction

Left ventricular hypertrophy (LVH) predicts mortality at start of dialysis. Prevention of of LVH is important. It is not known whether secondary hyperparathyroidism might induce LVH. In the present study patients are randomised to 1.25 dihydroxycholecalciferol or no treatment to study the effect on LVH.

Inclusion Criteria:

• Chronic kidney disease (S-creatinin > 150 and < 600 mikroM)
• Secondary hyperparathyroidism (Between 3-8 times the upper limit of our PTH assay)
• Stable blood pressure during the last 6 months (less than (160/95)
• B-hemoglobin > 6 mmol/l
• EKG with sinus rhythm and no sign of Q-wave infarction
• Expected follow up 6 month

Exclusion Criteria:

• Pregnancy
• Kidney transplantation
• Malignant disease