Campath-1H Induction to Allow Steroid Free Immunosuppression in Pediatric Renal Transplantation

Campath-1H Induction to Allow Steroid Free Immunosuppression in Pediatric Renal Transplantation

The purpose of this study is to determine whether Campath-1H induction and the associated lymphocyte depletion will permit long-term rejection-free renal allograft survival in the absence of ongoing corticosteroid administration.

Inclusion Criteria:

• Participants must be a single-organ recipient (kidney only)
• Participants who are receiving their first living donor or deceased donor transplant

Exclusion Criteria:

• Participants who are recipients of HLA-identical living-donor renal transplants
• Participants with a PRA value > 10% within 30 days prior to the transplant
• Participants who have received a multi-organ transplant
• Participants who are who are positive for hepatitis C, hepatitis B surface antigen or HIV
• Participants who have received an investigational drug within 6 weeks of study entry
• Participants who have a previous history of, or who currently have, malignancies and/or lymphoma
• Participants who have received corticosteroids within three months of transplantation
• Participants who are 3rd transplant recipients
• Female participants who are pregnant or lactating. Fertile female participants who are sexually active must agree to use an acceptable method of birth control during the study