Study of Dasatinib in Patients With Advanced Solid Tumors

Phase I Study to Evaluate the Effect of Ketoconazole on the Pharmacokinetics of Dasatinib and the Effect of Dasatinib on Pharmacodynamic Markers in Patients With Advanced Solid Tumors

The purpose of Segment 1 of the study is to determine the effect of ketoconazole on dasatinib. The purpose of Segment 2 is to learn how dasatinib affects tumor growth in patients with advanced solid tumors.

Inclusion Criteria:

• ECOG status 0-2
• Advanced or metastatic disease, unresponsive to standard treatment (or no standard treatment exists)
• Biopsy pretreatment
• Adequate bone marrow, liver and kidney function

Exclusion Criteria:

• Serious cardiovascular disease
• Bleeding disorders
• Gastrointestinal (GI) tract disease
• Platelet inhibitors
• H2 blockers, proton pump inhibitors