The Effect of Omeprazole on the Pharmacokinetics of Dasatinib in Healthy Subjects

The Effect of Omeprazole on the Pharmacokinetics of Dasatinib (BMS-354825) in Healthy Subjects

The purpose of this study is to assess the effect of omeprazole on the pharmacokinetics of dasatinib in healthy subjects and to assess the safety and tolerability of a single dose of dasatinib before and after 5 days of dosing with omeprazole in healthy subjects

Inclusion Criteria:

• Healthy subjects as determined by medical history, physical examination, ECGs, and clinical laboratory determinations

Exclusion Criteria:

• Women who are pregnant or breastfeeding
• Prior exposure to dasatinib