Evaluation of Eflornithine on Facial and Forearm Skin

A 24 Week Randomised Double Blind Placebo Controlled Study to Evaluate the Atrophogenic Potential of Eflornithine in the Treatment of Women With Excessive Facial Hair

The purpose of this study is to evaluate whether regular use of eflornithine 11.5% cream in treating women with facial hair will induce skin damage (atrophy) on the face and/or forearms

Inclusion Criteria:

• Female subjects with clinical diagnosis of facial hirsutism/excessive facial hair
• Women of childbearing potential must agree to use an effective form of birth control for the duration of the study
• Skin type I-IV
• Customary frequency of removal of facial hair two or more times per week

Exclusion Criteria:

• Pregnant or lactating women
• Severe inflammatory acne or presence of significant scarring on the face
• History of skin malignancy
• Connective tissue disorders