Zoledronic acid is a medicine being studied in people with low bone mass. Side effects such as headache, fever, muscle aches, and pains, may occur following the infusion. This study will investigate the use of over-the-counter medicines to improve these symptoms.

Inclusion Criteria:

• Women greater than or equal to 45 years and less than or equal to 75 years of age inclusive
• Low bone mineral density

Exclusion Criteria:

• Certain prior treatments for low bone mass/osteopenia
• Current use of medicines (prescription or non-prescription) for pain, fever, or inflammation
• Impaired kidney function

Other protocol-defined inclusion/exclusion criteria may apply.