Conditioning Regimens for Patients With Severe Aplastic Anemia Transplanted With Marrow From an Unrelated Donor

Conditioning Regimens for Patients With Severe Aplastic Anemia Transplanted With Marrow From an Unrelated Donor

A single arm dose optimization study in which all patients are given a fixed dose of Cytoxan (4 x 50 mg/kg) plus ATG (3 x 30 mg/kg) and the TBI dose starting at 3 x 200 cGy is escalated or de-escalated dependent upon engraftment and toxicity.

Inclusion Criteria:

• Life-threatening marrow failure of nonmalignant etiology;
• failure to respond to the best available immunosuppressive treatment;
• lack of a HLA-identical family member

Exclusion Criteria:

• Severe disease other than aplastic anemia that would severly limit the probability of survival during the graft procedure;
• HIV seropositive patients;
• clonal abnormalities or myelodysplastic syndrome;